Female subject of child-bearing potential not willing to use an acceptable method of birth control (i.e.Contraindication to any cytotoxic drug contained in the chemotherapy regimen.Hypersensitivity to bortezomib, boron, or mannitol.epidural cord compression, superior vena caval syndrome). Patients may be entered if they have had prior limited-field radiotherapy or a short course of glucocorticoids or single agent chemotherapy for an urgent local problem at diagnosis (e.g. Ability to understand and willingness to sign a written informed consent document.Total bilirubin 80% unconjugated hyperbilirubinemia without other known cause) unless impairment is due to organ involvement by lymphoma. Creatinine less than or equals to 2x ULN or creatinine clearance more than or equals to 50 ml/min AST and ALT less than or equals to 3x ULN. Laboratory tests: ANC more than or equals to 1000/mm3, platelet more than or equals to 75,000/mm3.Confirmed pathological diagnosis by the Department of Pathology SGH/NUH/TTSH. Why Should I Register and Submit Results?.Molecular remissions were documented in two patients with mantle cell NHL.īased on the results of this pilot study, we conclude that the R-GIFOX regimen is feasible, tolerable, effective and able to mobilize peripheral stem cells in patients with relapsed and refractory aggressive NHL. Failure-free survival was 79.6% at median follow-up of 6 months (range 2-12). Hematologic and extra-hematologic toxicity was tolerable. Effective CD34(+) cell mobilization was obtained in four of six eligible patients and two had ASCT. The overall response rate assessed after three courses of R-GIFOX was 77%, with seven complete responses and three partial responses. Thirteen patients completed at least three courses of therapy and were evaluable for response. The median number of R-GIFOX courses delivered was 4 (range 1-6). Patients had received a median of two previous treatment lines (range 1-4). Responses were evaluated by the integrated FDG-PET/IWC criteria after the third course and at the end of the entire program.įourteen patients (median age 63 years, range 37-78 years) with relapsed (n = 9) or primary progressive (n = 5) aggressive (diffuse large cell, mantle cell, follicular G3), advanced (stage IV 71%), poor risk (IPI 3-5 50%) NHL were accrued in this pilot study. Treatment was given every 2 weeks with G-CSF support (5 microg/kg/day or 10 microg/kg/day at the end of the third course for stem cell mobilization). R-GIFOX consisted of rituximab (375 mg/m(2) on day 1), gemcitabine (1000 mg/m(2) on day 2), oxaliplatin (130 mg/m(2) on day 3) and ifosfamide (5 g/m(2) on day 3) as a 24-h single infusion in patients aged 65 years. Patients were scheduled to receive three courses of therapy followed by mobilization and ASCT or three more courses if ineligible for ASCT. We evaluated the clinical activity, toxicity and mobilizing capacity of a new salvage regimen, which combines gemcitabine and oxaliplatin with ifosfamide and rituximab (R-GIFOX) in patients with relapsed and refractory CD20(+) NHL. Since high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) can cure a proportion of such patients, provided that a substantial tumor shrinkage is achieved, the development of more effective and less toxic salvage regimens remains a major challenge. The prognosis of patients with aggressive non-Hodgkin's lymphoma (NHL) relapsing or progressing after front-line therapy remains poor.
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The ISOL8 allows you to solo various bands of your master.Īnother tool used for monitoring, the ISOL8 by TBProAudio is a fantastic plugin that allows you to quickly monitor 5 bands of your mix or master. If you want to learn more about mid-side processing and stereo imaging, check out our blog post and video that covers this topic: Like all Voxengo plugins, an A B comparison tool allows the user to compare two sets of settings. In includes a correlation and balance meter.Ĭorrelation and right/left balance meters at the bottom of the plugin allow for close monitoring of your signal’s balance, and a stereograph on the right offers a quick way to visually understand the width of your mix or master. The side-gain function allows you to increase the gain of your side image, in turn making your mix or master wide. MSED is an encoder and decoder that can sum channels, separate stereo signals into Mid and Side, swap channels, invert phases, and a lot more.Ī mid-gain function allows you to increase the gain of your mid-channel, in turn making your mix or master more centered. MSED by Voxengo is a powerful tool for any mastering engineer looking to both monitor and affect their stereo image with one tool. We’ll master it for you and send you a free sample for you to review. If you’re looking to hear your mix professionally mastered, and processed with all analog equipment, send it to us here: Keep in mind that these plugins are in no particular order. Regardless of the type of mastering you do or the genre you work in, these plugins will be useful. Some emulate analog processing while others offer a clean and transparent sound. The plugins listed here range from eq, dynamics, distortion, and just as importantly metering. This can be a costly process, but fortunately, great and completely free plugins are being released almost every week that can be used to create fantastic-sounding masters.įree plugins often perform the same functions as costly ones.Īlthough the plugins listed here won’t cover every need you might have when mastering, hopefully at least one or two will be useful to you - in turn saving you some time and money. There’s a lot of trial and error that engineers have to go through before finding the best plugins for their style. Finding the right plugins for mastering isn’t always the easiest task. Use of this method may also prevent the typist from being able to see what has been typed without glancing away from the keys. Instead of relying on the memorized position of keys, the typist must find each key by sight. "Hunt and peck (two-fingered typing) is a common form of typing, in which the typist presses each key individually. Hunt and peck/two finger typing/keyboarding Specifically, a touch typist will know their location on the keyboard through muscle memory. Touch typing (also called touch type or touch method or touch and type method) is typing without using the sense of sight to find the keys. Some of these are easily confused, this confusion can easily led to 'much ado about nothing', for example no matter the enthusiasm for touch-typing, no one is considering abandoning the teaching of handwriting, cursive maybe, but handwriting? No. In the interests of clarity it's important to establish from the outset that there are at least four different ways of coding meaning using the symbols we call 'letters' that equate to sounds that we in turn translate into words, in other words- writing. I think it helps if we stop and consider what it is what we are really talking about, it's not about typing or writing, typing is writing, what do we mean when we talk about writing? The danger with this issue is that it quickly devolves into an 'us vs them' argument, this is not a an argument we need to have, and not one I intend to get drawn into here, besides others far more eloquent than I have already done this far better than I could, such as this article from The New York Times. Keyboarding removes this burden, enabling students to work on things like sentence structure and grammar while they type." ( Typing Club Handbook) When typing with two fingers (hunt and peck), "the visual and frontal cortices of the brain are forced to focus on where individual keys are located. Once you are able to type with all ten fingers without needing to look down at the keyboard, your overall productivity when using a computer will improve dramatically. This may come as a surprise to many, but typing faster is not the primary objective of learning to touch-type rather it is a desired side effect. All of this reading led me to the point I am now, namely a great deal more aware of the tensions, and especially the misconceptions that surround this issue. I worked with some colleagues to write an article on this very topic for the college magazine, Dunia, an exercise that required us to read a wide range of research on the topic, the outcome of which I have summed up at the bottom of this post if you're interested. Hunting for keys and pecking at the keyboard, before eventually, and with great trepidation, looking up at the screen only to be presented with a mangled representation of the thoughts I so diligently delivered with my not so deft strokes-littered with the red lines demanding that I attempt again to wrestle the meaning from the scrambled melange of words, words that barely resemble the ideas I am attempting to represent, even now fading from my short term memory… Have you ever sat in the proximity of someone writing who can touch-type? They sit nonchalantly in front of the screen, their fingers dancing over the keys meanwhile I sit hunched over the keyboard like Gollum, forehead facing the screen instead of, well, my face. The icicles are about a 10-minute walk from the Misoba bus stop. Take the Seibu Chichibu or Seibi Ikebukuro line to Seibu Chichibu Station, and then transfer to the Seibi Kanko Bus for Mitsumine-jinja. to 5 p.m., however on illumination days, closing hours are extended into the evening.Ī one-way trip takes about 2.5 to 3 hours from central Tokyo. There is an annual Otaki Ice Festival, during which the icicles are illuminated in the evening on weekends and national holidays, creating one of the most beautiful winter sights in Saitama. The best time to visit is mid-January to mid-February when the temperature is at its lowest. During winter, spring water solidifies and forms icy curtains on the surface of the rock wall. Take a short train ride north of Tokyo to neighboring Saitama prefecture to see the Misotsuchi icicles. You can get discounted return tickets called R-Kippu for ¥ 17,940 otherwise, both the Hokkaido Rail Pass and Japan Rail Pass fully cover the journey. The JR Okhotsk limited express train from Sapporo costs ¥ 7,370 one-way and takes about 5 hours and 30 minutes. You can fly into Memanbestu Airport from either Tokyo (starting from ¥ 10,000, 2 hours) or Sapporo (starting from ¥ 6,000, 45 minutes), and then take a bus into Abashiri ( ¥ 0, 35 minutes). To get to Abashiri, it’s best to plan ahead. They also have an observation room and a dome theater where visitors can experience how Okhotsk changes throughout the four seasons.Įvery February there is a drift ice festival in Abashiri featuring snow sculptures of all sizes that are illuminated in the evenings. There you can learn all about the drift ice, its route, and the area’s flora and fauna. For something a little more tame (and warm), visit the Okhotsk Sea Ice Museum of Hokkaidō. There are several ways to experience this natural wonder, including walking tours (on the ice!), boat tours on an icebreaker ship, and even snow-shoeing treks if you’d prefer to admire it from a distance. The ice floe (called ryūhyō in Japanese) arrives in mid-January and can last until March (and sometimes stick around until April). Eventually it reaches the Okhotsk Sea, along the coast of Abashiri City and the Shiretoko Peninsula in Hokkaidō. Sea ice in Hokkaidō | Photo by /mantaphotoĮvery winter, an expanse of drift ice makes its way from Russia’s Amur River to northeastern Japan. Double click on each text box to change the text to your own.Click a corner and drag it to enlarge the image so it fills the entire canvas.Click here to make a copy of the template.Remember, in Google Drawings, anything that is off the canvas WILL NOT appear when you download your completed image! Sweet! On this template, I’ve set up word art text boxes for the students, instructions off the canvas on the left side of the screen, and numerous image choices off of the canvas on the right side of the screen. So… I knew I had to steal this amazing idea and create a safe-for-school meme generator template that gives students choices of safe for school images (while still giving the awesome Nicole Donaldson all the kudos and credit she is due for the creative and innovative idea – thank you, Nicole, for sharing and collaborating with me)!Ĭlick here to grab your own copy of this template! And best of all – the assignment had STUDENTS TEACHING EACH OTHER about the concept (here, school rules – but potential for ANY topic).SAFE – not out on meme generator websites which can sometimes have vulgar or offensive words or images.When she told me about the assignment, I immediately knew I was in love! While each table had the same grumpy cat face, they all selected different school expectations to reinforce for their classmates in this super fun, silly, and engaging assignment. Instead of standing in the front of the room and going over school rules again, she gave students the assignment to create a meme (you know, those hilarious pictures you see on the internet with white text at the top and bottom) which exemplifies or explains a school rule in table groups using one safe-for-school (but still fun) image she selected. One of the awesome teachers I have the privilege of working with at Ault, Nicole Donaldson teaches 5th grade Language Arts, told me about a class meeting activity she recently had her students complete. ✔ Photo to text interface is eye-catching but easy to use. ✔ Background has a modern design when the Write on photos feature is used. ✔ Text Art is a great alternative as a photo text editor for Canva and PicsArt. ✔ Add visual effects: This feature creates many beautiful effects on the image., ✔ Basic image editing operations: Aggregating basic image editing features such as Resize images (Resize), Cutting images, turning images, creating round corners for the sides of an image, obscuring images, and the feature undo/ Redo saves time to edit images ✔ Make your own story with Photo Collage Maker, Story Maker ✔ Write text on photos - easily insert text on photos. ✔ Photo frame: There are many beautiful frame patterns that you can choose, all divided into different subjects so that you can find them easily. The amazing features of the Text Art - Photo text editor: ✔ Professional Design Interface with Ease of use to add text to photos ✔ Write on photos with various text effects, fonts & sample quotes ✔ Thousands of handpicked Packages of picturesque images ✔ Apply one of more than a hundred photo filters ✔ The huge updated text and image library helps you create more solid pictures than ever before. Write on photos with the #1 photo text editor tool. All the professional editing tools have been simpler than ever before. In addition to the main feature, add text to photos, you can insert a sticker, frame the image, create the effect, make the photo collage. The app protects you from losing your creatives with auto-saving features. □Write on photos like a PRO! TextArt is an amazing photo text editor that allows you to add text to photos! ✅Photo text editor is a free app that lets you easily write on and edit your photo like a professional with multiple available photo effects & functions. The best tool to add text to photos in 2023. It’s that easy.Start using Text Art - Add Text to Photos App a unique photo text editor. TextArt – add words to pictures is an amazing photo text editor that allows you to add text to photos fast and easily! Just upload your photo and add text over the photo by writing your text. Enhance your photos by adding sleek text on photos with one of the best apps to add text to photos in 2023.✍️WRITE ON PICTURES & GET PRO RESULTS IN SECONDSWrite on photos like a PRO! Adding text in a photo has never been this easy. The best tool to add text to photos in 2023.ADD TEXT ON PHOTO & APPLY 100+ PHOTO FILTERSDo you want to put words on pictures and need a free write on pictures app?Want to also use powerful photo editing filters and tools besides putting text on photos?You found the solution - Text Art - Add Text to Photos App, which is a powerful, simple, and unique photo text editor. 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I look forward to leveraging technology innovations and taking a step closer to living in the utopian society that John Maynard Keynes predicted - stating that, by 2030, humans will be able to work an average of 15 hours a week and dedicate the rest to leisure and creative tasks.The MZ-X500 is pretty big, and it does have its own learning curve to it (although the touch screen helps). RPA and other cognitive technologies are here to stay, and the potential for them to create a fundamental shift in the way humans work is enormous. To avoid under-resourcing change management activities, RPA sponsors need to set up clear goals and make sure to align the strategy, processes, technology and people. A poor communication plan and lack of executive and grassroots buy-in can lead to missed opportunities and failure to deliver full value. With bots searching all database systems, providing speedy responses to incoming requests and maintaining an audit trail of all requests, there’s no need for human intervention.Ī change management strategy is key to the success of a disruptive implementation such as RPA. This way, companies can set up a portal for data subjects to review their stored data and update or delete their personal information. Software robots can capture the information, interpret data, perform action items and provide a response to the requester, regardless of where data resides or of its formatting. With the regulation’s comprehensive policy to enable advanced data review rights and ongoing consent management, your marketing database is likely to deal with a flood of requests that can skyrocket operational costs. In the imminent proliferation of data privacy regulations worldwide, RPA can also play an important role in relieving the massive administrative burden that large regulatory policies such as the General Data Protection Regulation (GDPR) can present.It can reduce cycle time by automating the promotional materials packaging process for form submission to the regulatory department, tracking the promotional material shipments status, and recording price quotes in response to promo material print production bidding into an application. RPA can replace reactive troubleshooting with the proactive identification of issues associated with bulk shipments of promotional materials.This will enable you to send highly segmented emails to maximize conversion and sales opportunities. Bots can be programmed to monitor your client base’s policy status and identify gaps and opportunities for discounts and bundles.Automation can also assist with campaign management data collection through web scraping and information dissemination for both marketing and sales activities. This can include monitoring customer activities for opportunities of upselling through segmented campaign targeting and preparing data for customer subscription or warranty renewals. With RPA, you can automate a variety of tasks.If you’re implementing RPA in your organization, here are some tasks you can consider automating to free up your creative teams: RPA Can Be Applied In Many Ways To Help Your Team Marketing leaders need to work with their internal RPA sponsors to drive grassroots empowerment from day one to accelerate adoption. Organizations looking to digitize their marketing service chain might come across other roadblocks that include automating non-suitable processes, a lack of executive buy-in, employee onboarding, unrealistic goals, missed ROI, infrastructure constraints, security issues and other challenges that go along with most technology innovations. When it comes to marketing, RPA can prove to be highly beneficial and provide a competitive edge to early adopters, but when it comes to new technology implementations, employee resistance to change is almost a given, especially toward a solution that they feel can potentially replace their own jobs. Think about how Jen from accounting won’t be yawning from manually copying information from one document or system to another application anymore. Instead, they have reallocated these workers to focus on more knowledge-based, creative and strategic assignments, relieving their human employees from boring and repetitive work. At this point, most may wonder: Will these bots take my job? Fear not: Based on my research, the majority of the companies that have implemented RPA do not intend to lay off the workers who used to perform the tasks now automated by bots. It will look like this:įorm: IIO 3, Form ID: 0x1A7 To turn on bifurcation of ‘x4x4’ the correct value will be ‘0x0’ or ‘00’. For example IIO3 IOU2 variable # is ‘0x53C’ and the default value is ‘FF’. Look for each Variable for IOU2 and write down the address. Open the String file in your favorite text editor and search for IOU2 or whatever. From there extract the PE32 body and use IFR Extraction tool tool to extract the String file. Open the original bios file inside UEFITool and search for “IOU1 (IIO PCIe Port 3)” and double click the search result which will bring you to the Platform DXE drive module. Set all of them and save the file with a new name. If you’ve got a x16 slot your going to have to find the right IOU 0 or 1 port and set it to x8x8 or whatever you want. In my case I set IOU2 to x4x4 which maps to my x8 slot. Your going to have to set all of the IOU2 or whatever IOU # to the desired bifurcation setting. Open your Bios in AMIBCP and look for the IntelRCSetup section. MSI UEFI Shell files (google search), RU Bios Utility, AMIBCP 5.02 (version may vary depending on board) Going to have an adapter by weeks end or next week I hope. Note I have not yet tested this yet beyond noting the change in HWInfo. Wether or not manufacturers provide it is another story. According to the Intel datasheet for this processor bifurcation support is allowable. My test board is an MSI Godlike E7883 X99A board with a 6850K. For a lot of you with Asrock boards not a concern since Asrock provides Bifurcation support in their bios’s anyhow. So the solution here is to bifurcate the last slot into x4x4 mode and use a two slot riser adapter.įor many of you with other configurations such as ITX boards this is an invaluable technique. Of course I could use the two other PCI-E slots that share bandwidth with my GPU’s but that would mean having them operate at 8X/8X or 8X/16X and despite negligible performance difference was not what I wanted aesthetically. In my case I also have an onboard M.2 connector with an NVME drive but that is connected to the last PCI-E slot and the M.2 Onboard drive is forced to operate through the PCH at lesser performance which is not desirable. Because I now have a 40 lane cpu and my two GPU’s both take 16X lanes placing a NVME drive on the last slot leaves me with 4X lanes that are wasted. Recently I have been experimenting with splitting my last unused 8X PCI-E Slot in half. Therefore, it seems that the Blu-ray release for the Spider-Man threequel will unfortunately not include the deleted scenes, which has led to much disappointment among fans who are putting blame on Sony for falsely advertising the home media release. The second image comes from Reddit user u/bhlombardy, who shared what fans are currently getting on the No Way Home physical release: Sony PicturesĪs reported by LRM Online, this matches the bonus features included in the UK release for Spider-Man: No Way Home, which hit store shelves a week early. However, upon release, the Blu-ray now only lists 80 minutes of extra footage, switching out the deleted scenes for the "Spiders Unite" featurette on the casing. Realities Collide, Spiders Unite, and more!" Sony PicturesĬurrently, many online retailers, like Walmart, are still promoting the Blu-ray with the packaging mentioning the 90 minutes of bonus content. "Over 90 minutes of bonus content on Blu-ray including deleted & extended scenes, bloopers & gag reel The full list of details includes the following: The original packaging for the Blu-ray was listed with over 90 minutes of content, which included five deleted scenes, some of which have been teased in other reports. Reddit user u/Professional-Nature1 shared a disappointing update regarding the Blu-ray disc for Spider-Man: No Way Home, which just became available today. Blu-ray Release Disappoints No Way Home Fans However, even though the Blu-ray's release date is finally here, many fans aren't getting what they were promised in terms of quantity with those extra features. The Blu-ray disc was said to hold more than two dozen extras and featurettes, including numerous scenes that were deleted from the final cut of the already massive movie. This includes everything from high-definition photos of its main stars to multiple hidden details in No Way Home's script, although fans are looking forward to more on the Blu-ray disc as well. Over the past few weeks, Sony and Marvel have shared new looks into how this once-in-a-generation movie came to be, bringing together heroes and villains from all across the Multiverse. Now, the time has come for its physical Blu-ray release. With nearly two and a half hours of thrilling action from start to finish, fans couldn't get enough of the threequel as it became the sixth-highest grossing movie in box office history. Spider-Man: No Way Home is the Marvel Cinematic Universe's most recent theatrical release, having broken box office records and the internet alike upon its long-awaited debut in December 2021. |
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